專業資訊

Recent studies propose 40 Hz neural activity induction as a promising approach for managing Alzheimer's dementia (AD). However, traditional flickering light is suboptimal in addressing cognitive and neuropsychiatric symptoms (NPS) of AD. This study aims to investigate the clinical efficacy of a novel multi-luminaire lighting technology, with reduced perceptible flickering, for treating AD NPS.

Existing treatments for Alzheimer’s disease (AD) have questionable efficacy with a need for research into new and more effective therapies to both treat and possibly prevent the condition. This review examines a novel therapeutic modality that shows promise for treating AD based on modulating neuronal activity in the gamma frequency band through external brain stimulation.

Non-invasive Gamma ENtrainment Using Sensory stimulation (GENUS) at 40Hz reduces Alzheimer’s disease (AD) pathology such as amyloid and tau levels, prevents cerebral atrophy, and improves behavioral testing performance in mouse models of AD.

依據2021年世界衛生組織（WHO）出版的「公共衛生領域應對失智症全球現況報告」(Global status report on the public health response to dementia)指出，全球有超過5千5百萬名失智者，到2050年預計將成長至1億3千9百萬人。失智症相關成本為每年1.3兆美元，且至2030年若因照顧成本增加更有可能達到2.8兆美元。國際失智症協會（ADI）早在2015年全球失智症報告即指出，世界上每三秒就有一人罹患失智症。

By exposing mice to a unique combination of light and sound, MIT neuroscientists have shown that they can improve cognitive and memory impairments similar to those seen in Alzheimer’s patients. At left, the mouse cortex shows a reduction in amyloid plaques following visual and auditory stimulation, compared to the untreated mouse at right.

失智症（dementia，中國大陸作痴呆，香港作認知障礙症，澳門作腦退化症），DSM-5描述為一種嚴重程度不同且有多種致病亞型的主要神經認知障礙，國際疾病分類（ICD-11）也將失智症歸類為具有多種形式或亞類的神經認知障礙，屬於腦部疾病的一種，此症導致思考能力和記憶力長期而逐漸地退化，並使個人日常生活活動受到影響。其他常見症狀包含情緒問題、語言問題、還有行動能力降低，但個人意識卻不會受到影響。

Alzheimer's disease (AD) was the main cause of dementia in an aging society; unfortunately, there is no effective treatment for AD now. Meditation has been reported to thicken the cerebral cortex, and gamma wave at a frequency of 40 hertz (Hz) was recorded during the meditation process from the brain. Previous study showed that non-invasive scintillation gamma frequency oscillation increased the space in recognition and memory of auditory cortex hippocampal gyrus in AD mice model.

These varied music tracks have been designed by Dr. Lee Bartel to help with focus, learning and relaxation. Learning is enhanced through sounds with the musical intent to reduce stress while maintaining focus. This improved focus assists in staying "in the zone" while studying.

This study assessed the effect of stimulating the somatosensory system of Alzheimer’s disease (AD) patients at three stages of their illness with 40 Hz sound. In this AB cross-over study design, 18 participants (6 mild, 6 moderate, 6 severe) each participated in 13 sessions: one intake and 12 treatment.

台達於中華護智協會主辦的「樂齡照護健康防疫研討會」現場，首次發表展示台達M+護智燈。以自行研發的專利複頻技術結合閱讀燈設計，在舒適照明的同時，將腦部保健輕鬆融入日常，打造新型態的樂齡生活。

看好40Hz頻率波長的光線對失智症可能的保健功效，台達電25日宣布推出M+護智燈，以自行研發的專利複頻技術結合閱讀燈設計，在正常燈光中埋入40Hz頻率光波，號稱在舒適照明的同時，亦能將腦部保健融入日常。

美國時間9日，由臺裔科學家、麻省理工學院(MIT) Picower學習與記憶研究所所長蔡立慧聯合MIT麥戈文腦科學研究所(McGovern Institute)教授Ed Boyden創辦的Cognito Therapeutics，於2021年阿茲海默症和帕金森氏症國際年會(2021 AD/PD)上公布，其用創新聲光刺激腦神經元數位療法治療阿茲海默症患者的臨床2期成果，患者記憶與認知能力評分下降速度降低83%，腦萎縮也減少61%。

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高醫體系推出一系列健康講座，首場由大同醫院神經內科楊淵韓主任針對阿茲海默失智症的篩檢及病程預測，現場湧入許多民眾聽講。

楊淵韓主任表示，根據世衛估計，2050年全球失智症和阿茲海默症患者將增加2倍達1.39億，而失智症造成每年經濟損失超過1.3兆美元，從2020-2050年，這個數字將增加超過9倍，失智症成為最重要的健康和經濟挑戰之一....

失智症除認知功能障礙外，亦常伴隨情緒、行為、精神病症狀等「非認知症狀」。這些症狀會讓病人產生更多的不適感，也是照顧者主要的壓力來源。

「非認知症狀」包括憂鬱、妄想、認錯、幻覺及其他精神行為障礙。高達七、八成的失智症患者在其病程中會產生「非認知症狀」。